HIV research is important not only for the medical advancement of HIV treatment, but also for prevention. HIV disease is not without the possibility of multiple complications even with appropriate treatment. Therefore, further research is necessary to look at consequences of long-term therapy, and further adjunctive therapy to HIV treatment. There has been significant advancements over 25 years. From one drug therapy, we have now gone to a multiplicity of combinations available to us. This means that patients will live longer and be healthier. We are now moving into an era of prevention, not only of HIV disease itself but the long-term complications associated with long-term HIV treatment, as well as the aging process. This disease is definitely not going away, and it will require continued efforts in all age groups to look at all aspects of this disease.